Neurodegenerative Disorders and Prionopathies
نویسندگان
چکیده
منابع مشابه
Autophagy and neurodegenerative disorders
Accumulation of aberrant proteins and inclusion bodies are hallmarks in most neurodegenerative diseases. Consequently, these aggregates within neurons lead to toxic effects, overproduction of reactive oxygen species and oxidative stress. Autophagy is a significant intracellular mechanism that removes damaged organelles and misfolded proteins in order to maintain cell homeostasis. Excessive or i...
متن کاملTau and neurodegenerative disorders.
The mechanisms that render tau a toxic agent are still unclear, although increasing evidence supports the assertion that alterations of tau can directly cause neuronal degeneration. In addition, it is unclear whether neurodegeneration in various tauopathies occurs via a common mechanism or that specific differences exist. The aim of this review is to provide an overview of tauopathies from benc...
متن کاملAgeing and Neurodegenerative Disorders
1Life, Health and Environmental Science Department, University of L’Aquila, 67100 L’Aquila, Italy 2Neuropsychology Unit, IRCCS Santa Lucia Foundation, 00179 Rome, Italy 3School of Life & Health Sciences, Aston University, Birmingham, West Midlands B15, UK 4Division of Behavioral Neurology, Department of Neurology and Alzheimer’s Disease Research Center, National Cheng Kung University Hospital, ...
متن کاملNeurodegenerative disorders and their treatment.
This Society for Medicines Research symposium was held on June 6, 2007, at the Eli Lilly Research Centre in Windlesham, Surrey, United Kingdom. The meeting, organized by Eric Karran and Alan Palmer, reviewed the progress made, and the challenges still to be overcome, in discovering safe and effective therapies for the most common chronic neurodegenerative diseases: Alzheimer's disease, Parkinso...
متن کاملParkin Regulation and Neurodegenerative Disorders
Parkin is a unique, multifunctional ubiquitin ligase whose various roles in the cell, particularly in neurons, are widely thought to be protective. The pivotal role that Parkin plays in maintaining neuronal survival is underscored by our current recognition that Parkin dysfunction represents not only a predominant cause of familial parkinsonism but also a formal risk factor for the more common,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neurology & Neurophysiology
سال: 2013
ISSN: 2155-9562
DOI: 10.4172/2155-9562.1000e113